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Overcoming the challenges of single nuclei sequencing in your research
Time:2023-06-13 16:03:34  


Overcoming the challenges of single nuclei sequencing in your research


Join us on Wednesday June 21, 2023 at 10 AM CEST / 4 PM SGT for our webinar organized in collaboration with Front Line Genomics explaining how and when to use single nuclei sequencing, how to overcome some of the specific challenges associated with this approach, and how single nuclei sequencing can accelerate your research.

The adoption of single cell analysis approaches has accelerated rapidly, leading to new progress in our understanding of complex biological systems. However, there are many circumstances when single cell sequencing can be more challenging.

Single nuclei sequencing is a technique used to analyse information within individual cell nuclei rather than whole cells. It is particularly useful when working with frozen tissues, samples that are difficult to dissociate into single cells, or when studying cell types that do not survive the dissociation process.

What you will learn in this webinar:


  • What is single nuclei sequencing? How does it compare to single cell analysis, and under what circumstances can or should you use this approach? What are the advantages?
  • The advantages and limitations of single nuclei sequencing. What do you need to consider before using this approach?
  • How to use single nuclei sequencing to study frozen tissue to generate new results with old samples.
  • How you can optimise your use of single nuclei sequencing. Focusing not just on the technology itself, but also how to optimise the entire workflow for this approach.
  • A demonstration of how to use single nuclei sequencing, using a soon-to-be published case study focusing on skeletal muscle cells to study inclusion body myositis (IBM).


Talk 1: "Picking the right technology: A comparative analysis of data generated from single cell and single nuclei sequencing approaches."

The first talk is from Dr. Celia Fernandez-Sanz, Senior Application Scientist at Singleron Biotechnologies. In this talk, you will learn about the advantages and challenges of single cell and single nuclei sequencing approaches.

Talk 2: Case Study: "Cellular senescence of muscle-resident cells drives inflammation in inclusion body myositis."

The second talk by Dr. Christopher Nelke, Postdoctoral Researcher at the Department for Neurology, University Hospital Dusseldorf, Germany, is a case study using single nuclei sequencing to investigate the role of cellular senescence in inclusion body myositis (IBM), an inflammatory and treatment-refractory muscle disease.

Talks are followed by audience Q&A with both speakers.

Register here: Registration Link


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