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Instruments
Singleron PythoN Junior™ Singleron Matrix NEO™ Singleron Matrix® Singleron PythoN®
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Single Cell Kits
GEXSCOPE® Single Cell RNA Library Kit GEXSCOPE® Single Nucleus RNA Library Kit GEXSCOPE® Microbial Single Cell RNA Library Kit HD (Yeast) GEXSCOPE® Single Cell V(D)J Kit DynaSCOPE® Single Cell Dynamics RNA Library Kit FocuSCOPE® Single Cell Targeted Capture Kit sCircle® Single Cell Full Length Immunoreceptor Library Kit CLindex® Sample Multiplexing Kit sCelLiVE® Tissue to Living Single Cell Suspension Kit AccuraCode® RNA Library Construction Kit
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Technology
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Database
GEXSCOPE® Single Cell V(D)J Kit enables simultaneous detection of T-cell or B-cell receptor gene expression, together with whole transcriptome expression at single-cell level.
GEXSCOPE® Single Cell V(D)J Kit utilizes specially designed probes on beads to capture all T-cell/B-cell receptor constant regions, to construct the V(D)J library. At the same time, poly-T on beads is utilised to capture all mRNA in the same cell, to construct the whole transcriptome library.
Based on the high RNA binding specificity introduced by targeted probes, GEXSCOPE® Single Cell V(D)J Kit can achieve high capturing efficiency during RNA molecule enrichment. GEXSCOPE® V(D)J library generates high BCR/TCR diversity, high V(D)J mapping rates, and high medium UMI/gene per cell.
Figure: PBMC samples were analyzed using GEXSCOPE® Single Cell V(D)J Kits, TCR α and β chain mapping rate are as high as 82.57%; 99% of reads can be mapped to V(D)J region.GEXSCOPE® Single Cell V(D)J Kit can be used to analyze the composition, abundance and alterations of TCR/BCR molecules within a tissue at single-cell level. This can be applied for exploring tumor microenvironment, immune diseases, viral infection and infectious disease.
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