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Single Cell ATAC-seq Service

Our service for Transposase Accessible Chromatin with high-throughput single cell sequencing (ATAC-seq) is a technique designed to identify open chromatin regions within the genome at single cell resolution.

Service Highlights

Our End-to-End service offers comprehensive support throughout the entire ATAC-seq workflow from tissue dissociation to bioinformatics analysis, ensuring personalized assistance wherever needed.

Full service from tissue dissociation, nuclei extraction, to data analysis
7-weeks turn-around-time
Specialized in handling rare and challenging samples
PhD-level support for your technical requirements

Singleron's Single Cell ATAC-seq Solution

The scATAC-seq service offered by Singleron utilizes our SCOPE-chip technology to enable precise and sensitive genome-wide mapping of chromatin accessibility. 

The ATAC-Seq process begins with the exposure of genomic DNA to Tn5, a transposase known for its robust activity. Tn5 intricately cuts the DNA and preferentially targets areas of open chromatin, simultaneously inserting sequencing adapters in a step known as tagmentation. Following tagmentation, the DNA fragments are loaded onto the chip and captured by uniquely barcoded beads. These barcodes are then associated with the DNA fragments, forming libraries that are amplified through PCR before undergoing sequencing. Additionally, we executed single-cell Assay for Transposase-Accessible Chromatin using sequencing (scATAC-seq) on a tumor in parallel with single-cell RNA sequencing (scRNA-seq) to generate paired datasets elucidating cell-type-specific chromatin accessibility and transcriptional landscapes.

Workflow at a glance


Single Nuclei Suspension

Tn5 Transposition

Cell Partitioning, Lysis & Barcoding

Pre-Amplification, PCR and ATAC Library Generation


Bioinformatics Analysis

Demo Data

Precise annotation of single-cell transcriptome is achieved through marker genes in mouse embryo, followed by accurate annotation of single-cell ATAC cell atlas using the “label transferring” method.


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