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Podcast: How to Master Tissue Dissociation
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In this episode of our podcast “Simon’s Bench Talk”, our experts dive deep into the technical hurdles of turning solid tissue into single cell suspensions. We step away from the perfect textbook examples to discuss the real-world examples from the lab: tubes that arrive seemingly empty because the samples are too tiny to see, tricky tissues, and the clever workarounds used to save a project.

In this episode, you’ll learn:

  • The “Invisible” Sample: How we processed a Guinea pig ganglia biopsy that was too small to be weighed or seen—and still got 20,000 nuclei.
  • The C. elegans Struggle: Why the real challenge wasn’t the worm’s stubborn cuticle, but its thousands of eggs.
  • The Pancreas Paradox: Why a sample can look perfect under a microscope but fail in sequencing (and how to fix it).
  • Lab Hacks: The fractional digestion trick for protecting fragile cells and which tissues prefer a bit of extra seasoning.
  • Single Nuclei: When to stop fighting for whole cells and why pivoting to single-nuclei (snRNA-seq) is sometimes a strategic win rather than a compromise.

Expert: Celia Fernández-Sanz, PhD is a leading voice in the field of single cell sequencing. Based in Cologne, Germany, she heads Singleron’s service department, where she coordinates the processing of hundreds of diverse and often difficult sample types. Driven by a relentless drive to optimize and troubleshoot, Celia has developed an unmatched expertise in solving the specific bottlenecks—like tissue dissociation—that define the success of every single cell experiment.

Your Host: Samantha Langer, PhD After years of hands-on research at the bench, Samantha transitioned her scientific expertise into the world of science communication. Driven by a curiosity to uncover the real stories that standard protocols leave out, she bridges the gap between high-level genomics and the practical, reality of the lab.

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