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Can I measure cell surface protein glycosylation in single cells?

Yes. The ProMoSCOPE® Single Cell Glycosylation Detection Kit combines chemoenzymatic labeling of cell-surface glycans with single cell RNA sequencing, allowing simultaneous quantification of glycosylation and gene expression in the same individual cells.

The key technology is enzyme-mediated attachment of a DNA-tagged fucose molecule to N-acetyllactosamine (LacNAc) on the cell surface.

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