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Singleron Introduces PythoN i™, Adding Nuclei Extraction and Tissue Homogenization Functions to its Tissue Processing System

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COLOGNE, GERMANY – March 31, 2025 – Singleron Biotechnologies today announced the launch of PythoN i, an advanced tissue processing system that streamlines critical sample preparation steps for single cell sequencing, single nucleus sequencing, and DNA, RNA, and protein extraction.

PythoN i allows researchers to process up to eight samples concurrently with individualized temperature, rotation speed, duration, cycle number, and heating parameters. The system completes standard processing runs in just 15 minutes, significantly reducing sample preparation time.

“PythoN i integrates three essential tissue processing functions into a single platform,” said Julia Peisert, Product Manager at Singleron Biotechnologies. “Researchers can now perform tissue dissociation, nuclei extraction, and tissue homogenization with one instrument, eliminating the need for multiple specialized devices.”

The system’s nuclei extraction capability delivers reproducible results for frozen tissues and challenging sample types where single nucleus sequencing provides better representation of cell populations, such as brain and muscle tissues. Additionally, PythoN i offers fast and efficient tissue homogenization to facilitate the extraction of DNA, RNA, and proteins.

PythoN i integrates seamlessly with Singleron’s existing single cell and single nucleus sequencing workflows, providing researchers with a complete solution from sample preparation to analysis.

For more information about PythoN i, visit https://singleron.bio/products/pythoni-tissue-dissociation-automation/

About Singleron

Founded in 2018, Singleron Biotechnologies is dedicated to advancing human health through pioneering single cell multi-omics solutions. With a portfolio that includes instruments, reagents, bioinformatics software, and a comprehensive single cell knowledgebase, Singleron operates globally with offices and facilities in Germany, Singapore, the USA, and China. Singleron products are used in over 4,000 laboratories worldwide, spanning hospitals, research institutes, and pharmaceutical companies. For more information, visit www.singleron.bio

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